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Manager/Senior Manager, Business Operations

Location: Anywhere in the U.S. (Remote Position) – about 10-20% of travel once pandemic restrictions are resolved.

Xentria is a patient-centric biotech company focused on novel biologics and biosimilars. Our first program is XT MAB 16, a monoclonal antibody for sarcoidosis. XT MAB 16 has received Orphan Drug Designation and is currently in a Phase 1 study. 

The Manager/Senior Manager, Business Operations is responsible for the timely preparation, negotiation, and administration of clinical trial vendor contracts and accruals to ensure cost effective and accurate contracting services between the Company, its vendors and HCP's. The Manager/Senior Manager, Business Operations will partner with Clinical Operations, Legal, and Finance departments, as well as additional internal/external parties to identify contract needs, budgets, and other variables as needed.

Essential Duties and Responsibilities

  • Reviews and negotiate standard agreements, including confidential disclosure agreements,
  • consulting agreements, vendor work orders and other contracts relating to clinical trials as assigned.
  • Raises more complex situation to manager for guidance.
  • Partners with the Clinical Team on contracts to ensure all elements are accurate and meet the needs of the business, and to determine when new contracts and/or change orders may need to be initiated.
  • Utilizes and maintains tracking and database systems for contracts in a timely and accurate manner.
  • Creates & maintains department specific documents including those that support internal and outsourced business processes to support the clinical team, and clinical study team assignments.
  • Performs business operations tasks such as financial reconciliations and closing out relevant contracts and budgets.
  • Distributes Contract Update reports to the Clinical Development team to provide critical information regarding budgets, expenses and progress on contract timelines.
  • Works independently to facilitate resolution of routine contract and invoicing issues within consulting agreements, service agreements, and others as needed.
  • Provides updates to finance for assigned contracts with relevant spend and forecast future contract spend.
  • Leads project budget tracking across projects and assists in the development of program and vendor budgets.
  • Acts as liaison among internal stakeholders, external vendors/business partners to facilitate and engage in contract preparation, negotiation, and administration.
  • Monitors contracts to ensure compliance to corporate policies and procedures.
  • Initiates corrective action when noncompliance occurs.
  • Brings repeat noncompliance issues to manager for additional guidance and or resolution plan.
  • Contributes to process improvements, updating and/or revising templates and processes as needed.
  • Tracks health care professional agreements and budgets that are subject to Sunshine reporting.
  • Up to 20% domestic and/or international travel expected with occasional travel to Chicago office.

Supervisory Responsibilities

No direct reports associated at this time.


  • Agile
  • Analytical
  • Written and Verbal Communication Skills
  • Technically Savvy
  • Problem Solving
  • Project Management


To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

  • Strong analytical and problem-solving skills A sense of urgency balanced with adherence to policy and process.
  • The ability to influence without direct authority.
  • Results driven with demonstrated successful outcomes.
  • Ability and desire to work well with a diverse employee population and customers in a cooperative and friendly manner.
  • Must possess ability to handle multiple priorities in a fast-paced environment.
  • Must possess excellent written and verbal communications skills.
  • Must also be able to facilitate occasional projects not possible during normal business hours due to vendor necessity or customer impact (e.g. ability to be on call for any critical system issues)

Education and/or Experience Required

Bachelor's degree and at least 4 years of relevant experience in the biotech, device, or pharmaceutical industry.

AAP/EEO Statement

Equal Opportunity Employer Minorities/Women/Veterans/Disabled.  

Computer Skills

Microsoft Word, PowerPoint and Excel.  Technical software skills and experience, including ERP systems, Business Intelligence Tools, and experience optimizing data analytics to enact business decisions. 

Physical Demands

While performing the duties of this Job, the employee is frequently required to stand; walk; sit and talk or hear. The employee must occasionally lift and/or move up to 20 pounds. 

Work Environment

This is a remote position.

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About Us

Headquartered in Chicago, the company is dedicated to R&D, clinical science, manufacturing, and commercialization while striving to treat the clinical and social disease burdens while fostering sustainable growth. Xentria, whose name stems from the word “centrality” was founded in 2020 and is an innovative biopharmaceutics company whose primary focus is to build an expansive product pipeline of cost-effective and efficacious treatments to address critical unmet needs for patients suffering from rare, immunologic, metabolic, and musculoskeletal diseases, as well as oncology.

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